PLE catalysed enantiomeric separation of various (+/-)-6-acetoxy-alpha,beta-unsaturated cyclic ketones

Tanyeli C., Sezen B., Dikici E., Fleischhauer J., Repges C., Wang Y., ...More

ENANTIOMER, vol.6, no.4, pp.219-227, 2001 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 4
  • Publication Date: 2001
  • Journal Name: ENANTIOMER
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.219-227
  • Middle East Technical University Affiliated: Yes

Abstract

Various (+/-)-6-acetoxy-alpha,beta -unsaturated cyclic ketones were resolved by PLE catalysed hydrolysis to afford enantiomerically enriched 6-hydroxy derivatives with 85-98% e.e. The absolute configuration of 6-hydroxy-alpha,beta -unsaturated cyclic ketones were determined via CD measurements.