Akademik Veri Yönetim Sistemi
Scientific Reports, cilt.15, sa.1, 2025 (SCI-Expanded, Scopus)
Cochlear implants (CIs) are among the most established neuromodulation devices, providing auditory perception through electrical stimulation of the auditory nerve. While conventional stimulation strategies rely on symmetric biphasic rectangular pulses, alternative pulse shapes may offer improvements in neural activation and energy efficiency-particularly for fully implantable CI systems where power consumption is a key limitation. In this study, we investigate the efficacy of anodic-first ramped biphasic pulse shapes compared to conventional anodic-first rectangular pulses, using a custom-designed fully implantable cochlear implant (FICI) system in an in vivo guinea pig model. Electrically evoked auditory brainstem responses (eABRs) were recorded in response to four charge-balanced waveform types: Rectangular, RampUp, RampDown, and RampLong. In this single-subject feasibility study, ramped waveforms elicited significantly larger eABR amplitudes, steeper input-output functions, and shorter latencies compared to rectangular pulses. Additionally, we characterized transmission efficiency across the electrode–tissue interface by analyzing waveform spectra and their attenuation through a frequency-dependent medium model. After correcting for these medium-specific losses, in the anodic-first biphasic configuration, RampUp and RampLong pulses demonstrated up to 19–22% improvement in power efficiency relative to rectangular pulses at subthreshold response levels. These findings highlight the potential of ramped stimulation to reduce energy consumption without compromising-and in some cases enhancing-neural activation. Such improvements are especially valuable for fully implantable devices, supporting longer battery life and more sustainable stimulation strategies in next-generation CIs.