Spectroelectrochemical Investigation of Nuclease Active Pt(II) Complexes Containing Pyrrole Oxime

Erdogan D., Kayi H., Ozalp-Yaman S.

ELECTROCHIMICA ACTA, cilt.158, ss.333-341, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 158
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.electacta.2015.01.148
  • Dergi Adı: ELECTROCHIMICA ACTA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.333-341
  • Anahtar Kelimeler: Platinum, electrochemistry, UV-Vis spectroelectrochemistry, oxime, DFT calculations, MOLECULAR-ORBITAL METHODS, GAUSSIAN-BASIS SETS, DNA-BINDING, IMINOXYL RADICALS, ANTICANCER DRUGS, LIGANDS, PLATINUM(II), REDUCTION, TOXICITY, EXCHANGE
  • Orta Doğu Teknik Üniversitesi Adresli: Hayır

Özet

In this paper, the electrochemical oxidation of three Pt(II) complexes containing pyrrole oxime (HL) having a general formula of [Pt(NH3)Cl(L)] (1), [Pt(L)(2)] (2), and K[PtCl2(L)] (3) has been investigated by in-situ spectroelectrochemistry in dimethylformamide (DMF). An irreversible metal-based oxidation process occurs during the anodic scan for each of the three complexes. The electronic absorption spectral changes indicate that all the three complexes generate similar Pt(IV) compounds and free ligand. Our experimental data is supported by quantum chemistry calculations utilizing density functional theory. In addition, the frontier orbital energy distributions indicate that electron densities are localized on mainly platinum atom. (C) 2015 Elsevier Ltd. All rights reserved.