Gentamicin release from a hydroxyapatite - Gelatin composite

Yaylaoglu M., Korkusuz F., Hasirci V.

1st International Conference on Biomedical Materials, Ancona, Italy, 01 May 1997, vol.16, pp.149-154 identifier

  • Publication Type: Conference Paper / Full Text
  • Volume: 16
  • City: Ancona
  • Country: Italy
  • Page Numbers: pp.149-154
  • Middle East Technical University Affiliated: Yes


This study was carried out to develop a calcium phosphate-gelatin composite implant that would mimic the structure and function of bone to fill voids or gaps as well as to release bioactive compounds like drugs, hormones, etc to help tissue repair. XDS analysis of the calcium phosphate prepared revealed a calcium to phosphorus ratio of 2.30, which is significantly higher than that found in hydroxyapatite. Crystallisation of calcium phosphate within gelatin membrane also yielded a similar composition. The distribution of the mineral crystallised within the membrane was denser on the surface and this density diminished as the center is reached. SEM of the membrane also confirmed the presence of a surface with a different appearance than the interior.