Quaternized Polymer-Single-Walled Carbon Nanotube Scaffolds for a Chemiresistive Glucose Sensor

Soylemez S., Yoon B., Toppare L., Swager T. M.

ACS SENSORS, vol.2, no.8, pp.1123-1127, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 2 Issue: 8
  • Publication Date: 2017
  • Doi Number: 10.1021/acssensors.7b00323
  • Journal Name: ACS SENSORS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1123-1127
  • Keywords: chemiresistive glucose sensor, single-walled carbon nanotube, poly(4-vinylpyridine), quaternization, glucose oxidase, glucose detection in beverages, BIOSENSORS, COMPOSITES, SYSTEMS
  • Middle East Technical University Affiliated: Yes


A chemiresistive glucose sensor based on poly(4-vinylpyridine) (P4VP) and single-walled carbon nano tube (SWCNT) composites was reported. To fabricate this glucose sensor, a glass substrate containing gold electrodes was treated with 3-bromopropyltrichlorosilane to obtain a covalent bonding between the polymer SWCNT composite and the glass substrate. Some of the pyridyl moieties in P4VP react with the surface, and the remainders were quaternized using 2-bromoethanol to achieve highly charged hydrophilic surface with improved biocompatibility with enzyme molecules. The resulting biomimetic surface was functionalized with glucose oxidase (GOx) by electrostatic assembly with the quaternized P4VP-SWCNT composite. This material displays a decrease in electrical resistance as a result of enzymatically liberated hydrogen peroxide produced in response to glucose, which increases the p-doping of the SWCNT. The sensor exhibited high selectivity for glucose and showed an instant response (within 3 s) to glucose.