Enantioselective synthesis of hydroxy ketones through cleavage and formation of acyloin linkage. Enzymatic kinetic resolution via C-C bond cleavage

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Demir A., Pohl M., Janzen E., Muller M.

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, no.7, pp.633-635, 2001 (SCI-Expanded)

• Publication Type: Article / Article
• Publication Date: 2001
• Doi Number: 10.1039/b100341k
• Journal Name: JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.633-635
• Middle East Technical University Affiliated: Yes

Abstract

Both enantiomers of benzoins and (R)-2-hydroxy-1-phenylpropanone analogues were obtained in high yield on a preparative scale starting from aromatic aldehydes, rac-benzoins and aliphatic aldehydes via enzyme-catalysed C-C bond cleavage and C-C bond formation reactions.