Enantioselective synthesis of hydroxy ketones through cleavage and formation of acyloin linkage. Enzymatic kinetic resolution via C-C bond cleavage


Creative Commons License

Demir A., Pohl M., Janzen E., Muller M.

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, no.7, pp.633-635, 2001 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2001
  • Doi Number: 10.1039/b100341k
  • Journal Name: JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.633-635

Abstract

Both enantiomers of benzoins and (R)-2-hydroxy-1-phenylpropanone analogues were obtained in high yield on a preparative scale starting from aromatic aldehydes, rac-benzoins and aliphatic aldehydes via enzyme-catalysed C-C bond cleavage and C-C bond formation reactions.