Enantioselective synthesis of alpha-hydroxy ketones via benzaldehyde lyase-catalyzed C-C bond formation reaction

Demir A. , Sesenoglu O., Eren E., Hosrik B., Pohl M., Janzen E., ...Daha Fazla

ADVANCED SYNTHESIS & CATALYSIS, cilt.344, sa.1, ss.96-103, 2002 (SCI İndekslerine Giren Dergi) identifier


(R)-Benzoins and (R) -2-hydroxypropiophenone derivatives are formed on a preparative scale by benzaldehyde lyase (BAL)-catalyzed C-C bond formation from aromatic aldehydes and acetaldehyde in aqueous buffer/DMSO solution with remarkable case in high chemical yield and high optical purity. The substrate range of this thiamin diphosphate-dependent enzyme was examined with respect to a broad applicability of this benzoin condensation-type reaction in stereoselective synthesis.