Effects of Local Low-Dose Alendronate Injections Into the Distraction Gap on New Bone Formation and Distraction Rate on Distraction Osteogenesis
JOURNAL OF CRANIOFACIAL SURGERY, vol.28, no.8, pp.2174-2178, 2017 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 28 Issue: 8
- Publication Date: 2017
- Doi Number: 10.1097/scs.0000000000002615
- Journal Name: JOURNAL OF CRANIOFACIAL SURGERY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.2174-2178
- Keywords: Alendronate, bisphosphonates, bone regeneration, distraction osteogenesis, distraction rate, histopathology, rabbit mandible, MANDIBULAR DISTRACTION, MODEL, REGENERATION, BISPHOSPHONATES, INFUSION, RABBITS, LATENCY, TIBIA, MASS
- Middle East Technical University Affiliated: Yes
Abstract
Bisphosphonates that constrain bone resorption have a direct effect on osteoclast function. In this experimental study, the effects of low-dose local alendronate injections on the distraction gap (DG) in rabbit mandible at 2 different rates were evaluated.