Effects of Local Low-Dose Alendronate Injections Into the Distraction Gap on New Bone Formation and Distraction Rate on Distraction Osteogenesis

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Alp Y. E., Taskaldiran A., Onder M. E., KARAHAN S., KOÇYİĞİT İ. D., ATIL F., ...More

JOURNAL OF CRANIOFACIAL SURGERY, vol.28, no.8, pp.2174-2178, 2017 (SCI-Expanded, Scopus)

• Publication Type: Article / Article
• Volume: 28 Issue: 8
• Publication Date: 2017
• Doi Number: 10.1097/scs.0000000000002615
• Journal Name: JOURNAL OF CRANIOFACIAL SURGERY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.2174-2178
• Keywords: Alendronate, bisphosphonates, bone regeneration, distraction osteogenesis, distraction rate, histopathology, rabbit mandible, MANDIBULAR DISTRACTION, MODEL, REGENERATION, BISPHOSPHONATES, INFUSION, RABBITS, LATENCY, TIBIA, MASS
• Middle East Technical University Affiliated: Yes

Abstract

Bisphosphonates that constrain bone resorption have a direct effect on osteoclast function. In this experimental study, the effects of low-dose local alendronate injections on the distraction gap (DG) in rabbit mandible at 2 different rates were evaluated.