In most practical applications of performance-based earthquake engineering, the local site characteristics are considered simplistically, and soil-structure interaction effects are ignored. Within such a conventional approach, the ground motion record selection uses the time-averaged shear-wave velocity in the top 30 m of the soil profile (VS30) as the main proxy to represent the site where the structure is located. This study aims to assess the impact of local site effects on the risk assessment of reinforced concrete (RC) bridges by incorporating the local-site response and soil-structure interaction effects more realistically within a more detailed approach. For this pur-pose, seismic risk assessment of RC bridge structures with various configurations located on varying site char-acteristics was carried out using different levels of refinement in the numerical modelling. Local site amplification was incorporated using site response analysis, and p-y models were used to consider foundation flexibility. Cloud analyses were then carried out on both modelling approaches to obtain and compare the corresponding scenario-based seismic loss estimates for the structures. Moreover, the results of numerical ana-lyses were scrutinized in terms of peak demand to capacity ratio values, and statistical hypothesis testing was used to quantify the similarity between the two approaches further. In some cases of site response modeling, especially when the fundamental periods of the bridge structure and site are sufficiently close, higher displacement demands on bridge piers were obtained, likely leading to higher direct seismic losses.