Effects of carbamazepine on serum parathormone, 25-hydroxyvitamin D, bone specific alkaline phosphatase, C-telopeptide, and osteocalcin levels in healthy rats

KIR H. M., Garip S., ŞAHİN D., Oztas B.

BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol.12, no.4, pp.240-244, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 4
  • Publication Date: 2012
  • Journal Name: BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.240-244
  • Keywords: carbamazepine, bone-specific alkaline phosphatase, C-telopeptide, 25-hydroxyvitamin D, osteocalcin, PATIENTS RECEIVING CARBAMAZEPINE, MINERAL DENSITY, VITAMIN-D, ANTIEPILEPTIC DRUGS, ANTICONVULSANT THERAPY, CALCIUM-METABOLISM, GROWING RATS, EPILEPSY, TURNOVER, MONOTHERAPY
  • Middle East Technical University Affiliated: Yes

Abstract

It is still not completely clear whether carbamazepine causes alterations in vitamin D status and in bone metabolism. The objective of this study was to investigate the effects of carbamazepine on serum levels of 25-hydroxyvitamin D and on biomarkers of bone formation and resorption in healthy rats. Levels of calcium, 25- hydroxyvitamin D, parathormone, C-telopeptide, bone specific alkaline phosphatase and osteocalcin were measured in 3 groups of rats consisting of controls (n=10), isotonic saline solution group (n=10) and carbamazepine group (n=10). Mean calcium levels were found to be significantly lower in healthy controls in comparison to isotonic saline solution and carbamazepine groups (10.0+/-4, 10.81+/-0.16, 10.93+/-0.22 mg/dL, respectively, p<0.05). Mean levels of 25- hydroxyvitamin D, were found to be significantly higher in control group compared to isotonic saline solution group (25- hydroxyvitamin D; 25.91+/-1.12, 19.99+/-0.99 ng/mL, respectively, p<0.01.). Mean levels of parathormone and osteocalcin were found to be significantly higher in control group compared to isotonic saline solution group and carbamazepine group. Parathormone levels were measured as 3.46+/-0.83, 1.08+/-0.08, 0.94+/-0.02 pg/mL, respectively (p<0.01). Osteocalcine levels were measured as 1.66+/-0.001, 1.32+/-0.002, 1.32+/-0.001 ng/mL, respectively (p<0.001). A significant difference in terms of mean serum bone specific alkaline phosphatase and C-telopeptide levels among groups was not observed. The main outcome of this prospective study in healthy rats showed no change in biochemical parameters of bone turnover during treatment with carbamazepine. (C) 2012 Association of Basic Medical Sciences of FBH. All rights reserved