SYNTHESIS AND ANTIFUNGAL ACTIVITY OF SOME NEW BENZIMIDAZOLE DERIVATIVES


GOKER H., ERTAN R., AKGUN H., YULUG N.

ARCHIV DER PHARMAZIE, vol.324, no.5, pp.283-286, 1991 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 324 Issue: 5
  • Publication Date: 1991
  • Doi Number: 10.1002/ardp.19913240505
  • Title of Journal : ARCHIV DER PHARMAZIE
  • Page Numbers: pp.283-286

Abstract

Synthesis and antifungal evaluation of 5-ethoxycarbonyl-2-(substituted-benzyl or phenoxymethyl)benzimidazoles are reported. Structures of the compounds were elucidated with IR-, H-1-NMR-, C-13-NMR-, mass-spectra and elemental analysis. Preliminary results show that none of the synthesized benzimidazole derivatives has antifungal activity at the concentration of 100-mu-g/ml against Candida parapsilosis, Candida stellatoidea, and Candida pseudotropicalis.