A new species, Acantholimon karamanicum Akaychn & Dogan (Plumbaginaceae) is described and illustrated. The species grows on calcareous Mountain slopes in open Quercus sp. scrub, Astragalus sp. steppe, and inside Abies cilicica forest in Ermenek (Karaman). Diagnostic morphological characteristics from closely related species are discussed and conservation statuses of the species are given. A revised key to the Acantholimon species, with densely distichous spikes and outer bracts twice as long as the internodes, is also provided for the species found in Turkey.