Identification of biomarkers associated with partial epithelial to mesenchymal transition in the secretome of slug over-expressing hepatocellular carcinoma cells

Karaosmanoglu O., BANERJEE S., SİVAS H.

CELLULAR ONCOLOGY, vol.41, no.4, pp.439-453, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 4
  • Publication Date: 2018
  • Doi Number: 10.1007/s13402-018-0384-6
  • Journal Name: CELLULAR ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.439-453
  • Keywords: Hepatocellular carcinoma, Chemo-resistance, Partial EMT, Non-invasive biomarkers, Exosomes, Fibronectin 1 (FN1), Collagen type II alpha 1 (COL2A1), Fibrinogen gamma chain (FGG), TRANSCRIPTION FACTORS SNAIL, II COLLAGEN, FIBRONECTIN EXPRESSION, CISPLATIN RESISTANCE, ABERRANT EXPRESSION, THYROID-CANCER, TUMOR-CELLS, EMT, GROWTH, MIGRATION
  • Middle East Technical University Affiliated: Yes

Abstract

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Complete epithelial to mesenchymal transition (EMT) has long been considered as a crucial step for metastasis initiation. It has, however, become apparent that many carcinoma cells can metastasize without complete loss of epithelial traits or with incomplete gain of mesenchymal traits, i.e., partial EMT. Here, we aimed to determine the similarities and differences between complete and partial EMT through over-expression of the EMT-associated transcription factor Slug in different HCC-derived cell lines.