Simple chemoenzymatic access to enantiopure pharmacologically interesting (R)-2-hydroxypropiophenones

Demir A. , Hamamci H. , Sesenoglu O., Aydogan F., Capanoglu D., Neslihanoglu R.

TETRAHEDRON-ASYMMETRY, vol.12, no.13, pp.1953-1956, 2001 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 13
  • Publication Date: 2001
  • Doi Number: 10.1016/s0957-4166(01)00346-9
  • Title of Journal : TETRAHEDRON-ASYMMETRY
  • Page Numbers: pp.1953-1956


A chemoenzymatic synthesis of pharmacological interesting (R)-2-hydroxypropiophenones starting from propiophenone derivatives is described. Manganese(III) acetate-mediated acetoxylation followed by fungus-mediated hydrolysis of propiophenone derivatives affords (R)-2-hydroxypropiophenones in high enantiomeric excess. (C) 2001 Elsevier Science Ltd. All rights reserved.