Metabolic changes in schizophrenia and human brain evolution

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Khaitovich P., Lockstone H. E., Wayland M. T., Tsang T. M., Jayatilaka S. D., Guo A. J., ...More

GENOME BIOLOGY, vol.9, no.8, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 8
  • Publication Date: 2008
  • Doi Number: 10.1186/gb-2008-9-8-r124
  • Journal Name: GENOME BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Middle East Technical University Affiliated: No


Background: Despite decades of research, the molecular changes responsible for the evolution of human cognitive abilities remain unknown. Comparative evolutionary studies provide detailed information about DNA sequence and mRNA expression differences between humans and other primates but, in the absence of other information, it has proved very difficult to identify molecular pathways relevant to human cognition.