Selective monitoring and treatment of neuroblastoma cells with hydrogen sulfide activatable phototheranostic agent

Dirak M., Kepil D., Almammadov T., Elmazoglu Z., Cetin S., Ozogul N., ...Daha Fazla

Dyes and Pigments, cilt.210, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 210
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1016/j.dyepig.2022.111011
  • Dergi Adı: Dyes and Pigments
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

© 2022 Elsevier LtdActivity-based photosensitizers (aPSs) are highly attractive as they offer improved selectivity and better therapeutic outcome in the scope of photodynamic therapy (PDT). Here, a hydrogen sulfide (H2S) responsive iodinated resorufin-based PS (RHS) was developed to treat neuroblastoma cancer cells selectively. RHS was shown to be a phototheranostic agent as it turned on its fluorescence signal and singlet oxygen (1O2) generation capability after reacting with H2S. RHS exhibited remarkable sensitivity towards H2S and proved to be highly cytotoxic in H2S rich SH-SY5Y human neuroblastoma cells upon light irradiation. In contrast, no photocytotoxicity was observed in H2S deficient nonmalignant fibroblast L929 cells. RHS marks the first example of a resorufin-based H2S activatable phototheranostic agent, which paves the way for effective treatment of neuroblastoma through PDT modality.