Selective monitoring and treatment of neuroblastoma cells with hydrogen sulfide activatable phototheranostic agent


Dirak M., Kepil D., Almammadov T., Elmazoglu Z., Cetin S., Ozogul N., ...More

Dyes and Pigments, vol.210, 2023 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 210
  • Publication Date: 2023
  • Doi Number: 10.1016/j.dyepig.2022.111011
  • Journal Name: Dyes and Pigments
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
  • Middle East Technical University Affiliated: Yes

Abstract

© 2022 Elsevier LtdActivity-based photosensitizers (aPSs) are highly attractive as they offer improved selectivity and better therapeutic outcome in the scope of photodynamic therapy (PDT). Here, a hydrogen sulfide (H2S) responsive iodinated resorufin-based PS (RHS) was developed to treat neuroblastoma cancer cells selectively. RHS was shown to be a phototheranostic agent as it turned on its fluorescence signal and singlet oxygen (1O2) generation capability after reacting with H2S. RHS exhibited remarkable sensitivity towards H2S and proved to be highly cytotoxic in H2S rich SH-SY5Y human neuroblastoma cells upon light irradiation. In contrast, no photocytotoxicity was observed in H2S deficient nonmalignant fibroblast L929 cells. RHS marks the first example of a resorufin-based H2S activatable phototheranostic agent, which paves the way for effective treatment of neuroblastoma through PDT modality.