Reactions of 2-substituted epichlorohydrins

Tanyeli C., Demir A., Akhmedov I., Ozgul E., Kandemir C.

SYNTHETIC COMMUNICATIONS, vol.26, no.16, pp.2967-2980, 1996 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 16
  • Publication Date: 1996
  • Doi Number: 10.1080/00397919608004600
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2967-2980
  • Middle East Technical University Affiliated: Yes


2-Substituted epichlorohydrins have been synthesized by starting with 1,2-dichloro acetone and various alkyl and aryl halides via dichlorohydrins followed by cyclization. The reactive 2-substituted epichlorohydrins were subjected to nucleophilic attacking of azide and cyanide ions to afford corresponding beta-azido alcohols and alpha,beta-unsaturated nitriles.