This study investigated the effectiveness of bleaching agents on the micro tensile bond strength (mu TBS) of self-adhesive luting cement and enamel. A total of 126 samples were prepared from the labial surfaces of permanent human maxillary central incisors and assigned into three groups with 42 samples each as: control, enamel bleached with 10% hydrogen peroxide (HP), and enamel bleached with 10% carbamide peroxide (CP). Rely X Unicem (R) (3 M, ESPE) was used as self-adhesive resin cement. The total testing period for bleaching was selected as 14 days and the bleaching agents were applied 8 hours a day. The statistical one-way ANOVA model and Tukey HSD multiple comparison test (alpha = .01) were used to assess the differences. The control group demonstrated the highest value (18.245 MPa) while HP and CP showed the much lower values of 11.150 and 14.222 MPa, respectively. Bleaching agents affect the mTBS negatively. Failure analysis of the fracture surfaces demonstrated that almost all samples showed adhesive failures at the cement-enamel interface.