In vivo half life of nanoencapsulated L-asparaginase

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Atıf İçin Kopyala

Baran E., Ozer N., Hasirci V.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, cilt.13, sa.12, ss.1113-1121, 2002 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 13 Sayı: 12
• Basım Tarihi: 2002
• Doi Numarası: 10.1023/a:1021125617828
• Dergi Adı: JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.1113-1121
• Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

In the present study, antileukemic enzyme L-asparaginase (ASNase) was encapsulated into poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanocapsules in order to decrease the immunogenicity and toxicity of the enzyme and to increase its in vivo half life in mice.