Copy For Citation
Hoffmann T., Marion A., Antes I.
BMC STRUCTURAL BIOLOGY, vol.17, 2017 (SCI-Expanded)
Article / Article
BMC STRUCTURAL BIOLOGY
Science Citation Index Expanded (SCI-EXPANDED), Scopus
T-cell recognition, TCR structural modeling, Epitope prediction, Glutamine side chain prediction, Protein domain association angles, Immunoinformatics, Adoptive T-cell therapy, Vaccine design, MAJOR HISTOCOMPATIBILITY COMPLEX, CROSS-REACTIVITY, STRUCTURE VALIDATION, PROTONATION STATES, BINDING-AFFINITY, HYDROGEN-ATOMS, TCR, RECOGNITION, DOCKING, SELF
Middle East Technical University Affiliated:
Background: T cell receptor (TCR) molecules are involved in the adaptive immune response as they distinguish between self- and foreign-peptides, presented in major histocompatibility complex molecules (pMHC). Former studies showed that the association angles of the TCR variable domains (Va/V beta) can differ significantly and change upon binding to the pMHC complex. These changes can be described as a rotation of the domains around a general Center of Rotation, characterized by the interaction of two highly conserved glutamine residues.