Enzyme catalyzed hydroxymethylation of aromatic aldehydes with formaldehyde. Synthesis of hydroxyacetophenones and (S)-benzoins


Demir A. , Ayhan P., Igdir A., Duygu A.

TETRAHEDRON, cilt.60, ss.6509-6512, 2004 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 60 Konu: 31
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1016/j.tet.2004.06.015
  • Dergi Adı: TETRAHEDRON
  • Sayfa Sayıları: ss.6509-6512

Özet

Benzaldehyde lyase from the Pseudomonas Fluorescens catalyzed reaction of aromatic aldehydes with formaldehyde providing 2-hydroxy-1-arylethan-1-one in high yields via an acyloin linkage. Kinetic resolution of rac-benzoins with formaldehyde providing (S)-benzoins and 2-hydroxy-1-arylethan-1-one via C-C bond cleavage and a bond formation reaction. (C) 2004 Elsevier Ltd. All rights reserved.