Backgrounds Health professionals are among the frontline of COVID-19 pandemic exposure and identified as a priority target group that need to receive COVID-19 vaccines. However, intention to receive vaccine is still matters the extent of COVID-19 vaccinations among health professionals. This study aimed to assess intention to receive COVID-19 vaccine and the factors that will determine their intention among health professionals working at public hospitals of Illu Aba Bora and Buno Bedelle zone hospitals. Methods A cross-sectional study design was applied to assess the intention to receive COVID-19 vaccines among health professionals working in public health hospitals of Illu Aba Bora and Buno Bedelle zone hospitals. Self-administered questionnaire were used for assessing intention to receive COVID-19 Vaccine. Multiple linear regressions were performed to identify factors associated with intention to receive COVID-19 vaccine with p-value< 0.05 as cutoff point for statistical significance at 95% confidence interval (CI). Result In this study, almost half of respondents 217(53.1% [95.0%: CI 49.3-58.9]) of study participants scored above the mean. Attitude (beta = 0.54, 95% CI: [0.49, 0.63], p<0.01), knowledge (beta = 0.27, 95% CI: [0.21, 0.35], p<0.01, perception (beta = 0.43, 95% CI: [0.39, 0.56], p = 0.02 and age (beta = 0.64, 95% CI: [0.51, 0.72], pConclusions This study result indicated that the overall magnitude of intention to receive COVID-19 is low. increasing attitudes, knowledge and perception among health professionals related to COVID-19 vaccine will helps to increase the overall intention to receive vaccine against COVID-19.