Benzaldehyde lyase-catalyzed enantioselective carboligation of aromatic aldehydes with mono- and dimethoxy acetaldehyde


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Demir A. , Sesenoglu O., Dunkelmann P., Muller M.

ORGANIC LETTERS, cilt.5, sa.12, ss.2047-2050, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 5 Konu: 12
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1021/ol034415b
  • Dergi Adı: ORGANIC LETTERS
  • Sayfa Sayıları: ss.2047-2050

Özet

Benzaldehyde lyase from the Pseudomonas fluorescens catalyzes the reaction of aromatic aldehydes with methoxy and dimethoxy acetaldehyde and furnishes (R)-2-hydroxy-3-methoxy-1-arylpropan-1-one and (R)-2-hydroxy-3,3-dimethoxy-1-arylpropan-1-one in high yields and enantiomeric excess via acyloin linkage. Aromatic aldehydes and benzoins are converted into enamine-carbanion-like intermediates prior to carboligation.