PROTEIN AND PEPTIDE LETTERS, vol.28, no.2, pp.205-220, 2021 (SCI-Expanded)
Article / Article
PROTEIN AND PEPTIDE LETTERS
Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, EMBASE, MEDLINE
Cephamycin C, Streptomyces clavuligerus, hom-disruption, proteomics, MALDI-TOF/MS, nanoLC-MS/MS, CLAVULANIC ACID PRODUCTION, SECONDARY METABOLISM, HETEROLOGOUS EXPRESSION, ANTIBIOTIC PRODUCTION, BIOSYNTHETIC GENES, DEHYDROGENASE GENE, CRYSTAL-STRUCTURE, TETR FAMILY, SYSTEM, COELICOLOR
Middle East Technical University Affiliated:
Background: Streptomyces clavuligerus is prolific producer of cephamycin C, a medically important antibiotic. In our former study, cephamycin C titer was 2-fold improved by disrupting homoserine dehydrogenase (hom) gene of aspartate pahway in Streptomyces clavuligerus NR-RL 3585.