Gold(I)/Zn(II) catalyzed tandem hydroamination/annulation reaction of 4-yne-nitriles


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DEMİR A. G. , Emrullahoglu M., Buran K.

CHEMICAL COMMUNICATIONS, vol.46, no.42, pp.8032-8034, 2010 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 42
  • Publication Date: 2010
  • Doi Number: 10.1039/c0cc02357d
  • Journal Name: CHEMICAL COMMUNICATIONS
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.8032-8034

Abstract

The tandem hydroamination-annulation reaction of 4-pentyne-nitriles in the presence of amine nucleophiles and a cooperatively operating catalyst system, consisting of Ph(3)PAuCl and Zn(ClO(4))(2), provides an efficient route to 2-aminopyrroles. Two regioisomeric 2-aminopyrroles were formed in moderate to good yields.