Upregulation of multi drug resistance genes in doxorubicin resistant human acute myelogeneous leukemia cells and reversal of the resistance

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BARAN Y., Guer B., Kaya P., Ural A. U., Avcu F., GÜNDÜZ U.

HEMATOLOGY, vol.12, no.6, pp.511-517, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 6
  • Publication Date: 2007
  • Doi Number: 10.1080/10245330701562535
  • Journal Name: HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.511-517
  • Keywords: multidrug resistance, MDR1, MRP1, AML, doxorubicin, cytosine arabinoside, ACUTE MYELOID-LEUKEMIA, CYTOSINE-ARABINOSIDE, MDR MODULATION, PHASE-II, CANCER, EXPRESSION, CYCLOSPORINE, TRANSPORTERS, VINCRISTINE, MECHANISMS
  • Middle East Technical University Affiliated: Yes

Abstract

The major problem in the treatment of acute myeloid leukemia (AML) patients results from multidrug resistance to administered anticancer agents. Drug resistance proteins, MDR1 and MRP1, which work as drug efflux pumps, can mediate the multidrug resistance of human leukemia cells. In this study, the mechanisms of resistance to doxorubicin-induced cell death in human HL60 AML cells were examined.