Upregulation of multi drug resistance genes in doxorubicin resistant human acute myelogeneous leukemia cells and reversal of the resistance

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BARAN Y., Guer B., Kaya P., Ural A. U., Avcu F., GÜNDÜZ U.

HEMATOLOGY, cilt.12, sa.6, ss.511-517, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 6
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1080/10245330701562535
  • Dergi Adı: HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.511-517
  • Anahtar Kelimeler: multidrug resistance, MDR1, MRP1, AML, doxorubicin, cytosine arabinoside, ACUTE MYELOID-LEUKEMIA, CYTOSINE-ARABINOSIDE, MDR MODULATION, PHASE-II, CANCER, EXPRESSION, CYCLOSPORINE, TRANSPORTERS, VINCRISTINE, MECHANISMS
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

The major problem in the treatment of acute myeloid leukemia (AML) patients results from multidrug resistance to administered anticancer agents. Drug resistance proteins, MDR1 and MRP1, which work as drug efflux pumps, can mediate the multidrug resistance of human leukemia cells. In this study, the mechanisms of resistance to doxorubicin-induced cell death in human HL60 AML cells were examined.