HEMATOLOGY, vol.12, no.6, pp.511-517, 2007 (SCI-Expanded)
Article / Article
Science Citation Index Expanded (SCI-EXPANDED), Scopus
multidrug resistance, MDR1, MRP1, AML, doxorubicin, cytosine arabinoside, ACUTE MYELOID-LEUKEMIA, CYTOSINE-ARABINOSIDE, MDR MODULATION, PHASE-II, CANCER, EXPRESSION, CYCLOSPORINE, TRANSPORTERS, VINCRISTINE, MECHANISMS
Middle East Technical University Affiliated:
The major problem in the treatment of acute myeloid leukemia (AML) patients results from multidrug resistance to administered anticancer agents. Drug resistance proteins, MDR1 and MRP1, which work as drug efflux pumps, can mediate the multidrug resistance of human leukemia cells. In this study, the mechanisms of resistance to doxorubicin-induced cell death in human HL60 AML cells were examined.