EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, vol.47, no.4, pp.315-318, 1994 (SCI-Expanded)
Article / Article
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
Science Citation Index Expanded (SCI-EXPANDED), Scopus
Middle East Technical University Affiliated:
One hundred healthy Turkish Volunteers (70 male, 30 female) aged from 19 to 56 years were given 5 mg coumarin p.o. after an overnight fast. Urine samples were collected before and 2, 4 and 8 h after drug administration. The extent and rate of formation of 7-OH-coumarin (7OHC) was determined by the urinary excretion of the metabolite as measured with the fluorometric method.