INTERINDIVIDUAL VARIABILITY OF COUMARIN 7-HYDROXYLATION IN A TURKISH POPULATION

ISCAN M., ROSTAMI H., ISCAN M., GURAY T., PELKONEN O., RAUTIO A.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, vol.47, no.4, pp.315-318, 1994 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 4
  • Publication Date: 1994
  • Doi Number: 10.1007/bf00191161
  • Journal Name: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.315-318
  • Middle East Technical University Affiliated: Yes

Abstract

One hundred healthy Turkish Volunteers (70 male, 30 female) aged from 19 to 56 years were given 5 mg coumarin p.o. after an overnight fast. Urine samples were collected before and 2, 4 and 8 h after drug administration. The extent and rate of formation of 7-OH-coumarin (7OHC) was determined by the urinary excretion of the metabolite as measured with the fluorometric method.