Zn doped CaP coatings used for controlling the degradation rate of MgCa1 alloy: In vitro anticorrosive properties, sterilization and bacteria/cell-material interactions

Schmidt J., Pana I., Bystrova A., Dinu M., Dekhtyar Y., Vitelaru C., ...Daha Fazla

Colloids and Surfaces B: Biointerfaces, cilt.222, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 222
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1016/j.colsurfb.2022.113087
  • Dergi Adı: Colloids and Surfaces B: Biointerfaces
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Biotechnology Research Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, EMBASE, INSPEC, MEDLINE, Metadex, Civil Engineering Abstracts
  • Anahtar Kelimeler: Coatings, Corrosion resistance, Magnesium alloy, Degradation, Antibacterial activity, BIODEGRADABLE MAGNESIUM IMPLANTS, CALCIUM-PHOSPHATE COATINGS, MECHANICAL-PROPERTIES, SUBSTITUTED HYDROXYAPATITE, BIOMEDICAL APPLICATIONS, CORROSION BEHAVIOR, ZINC, MG, MICROSTRUCTURE, ENHANCEMENT
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

© 2022 Elsevier B.V.The purpose of this study was to investigate the effect of Zn doped CaP coatings prepared by micro-arc oxidation method, as a possible approach to control MgCa1 alloy degradation. All the prepared coatings comprised a calcium deficient CaP phase. The control in this evaluation was performed with undoped CaP coating in SBF solution at body temperature (37 ± 0.5⁰C). The investigation involved determination of microchemical, mechanical, morphological, properties along with anticorrosive, cytocompatibility and antibacterial efficacy. The effect of sterilization process on the properties of the surfaces was also investigated. The results showed that the addition of Zn into CaP increased the corrosion resistance of MgCa1 alloy. Moreover, the adhesion strength of the coatings to MgCa1 alloy was enhanced by Zn addition. In cytotoxicity testing of the samples, extracts of the samples in MEM were incubated with L929 cells and malformation, degeneration and lysis of the cells were examined microscopically after 72 h. The results showed that all samples were cytocompatible. The degradation of MgCa1 alloy in the simulated body fluids (SBF) or DMEM was decreased by coating with CaP. Moreover, the degradation rate of CaP was further decreased by adding a small amount of Zn into the CaP matrix. The samples having CaP coatings and Zn doped CaP coating demonstrated antibacterial efficacy against E.coli. As a result, coating of magnesium alloy with Zn-doped CaP decreased the degradation rate, increased the corrosion resistance, cytocompatibility and the antibacterial effects of the alloys.