There are different types of tsunami sources in Southern Aegean Sea. Wider awareness, proper preparedness and effective mitigation strategies against tsunamis need better understanding of tsunamis. Tsunami assessment study covers the exchange and enhancement of available earthquake and tsunami data, development of bathymetric and topographic data in sufficient resolution, selection of possible or credible tsunami scenarios, selection and application of the valid and verified numerical tools for tsunami generation, propagation, coastal amplification, inundation and visualization. From this point of view, tsunami analysis is applied to Southern Aegean Sea. Different tsunami sources are selected. The difficulties in defining the input parameters and uncertainties in the selected tsunami source characteristics are discussed. The simulations in nested domains for selected regions in Southern Aegean are performed using the tsunami numerical code NAMI DANCE. Moreover, the performance and efficiency of the numerical code, the estimations on near shore tsunami parameters (maximum water level, run-up, and inundation distance and arrival time) are discussed. Copyright © 2012 by the International Society of Offshore and Polar Engineers (ISOPE).