The performance of beam-to-column connections subjected to reversed cyclic loading depends on several variables. In this investigation, the effects of eccentric spandrel beams, wide normal beams, column section aspect ratio, loading in two principal directions, and slab participation on the inelastic behavior of beam-to-column connections are studied. The experimental program features three 3/4-scale exterior reinforced concrete beam-column-slab subassemblies. The major design variables for the specimens are the eccentricity of the spandrel beam with respect to column, beam and column section aspect ratios, and joint shear stress level. Results of the experimental program, including load-displacement response, beam plastic hinge rotation, joint distortion, and bond deterioration are presented in this paper.