This study compares the seismic performances of two reinforced concrete frame specimens tested by the pseudo-dynamic procedure. The pair of 3-storey, 3-bay frames specimens are constructed with typical characteristics of older construction which is lacking seismic design. One of the specimens is a bare frame while the other is infilled with low-strength autoclave aerated concrete (AAC) block masonry. The focus of this study is to investigate the influence of low strength masonry infill walls on the seismic response of older RC frames designed for gravity loads. It is found that the presence of weak infill walls considerably reduce deformations and damage in the upper stories while their influence at the critical ground story is not all that positive. Infill walls tend to localize damage at the critical story due to a peculiar frame-infill interaction, and impose larger internal force and deformation demands on the columns and beams bounding the infills. Therefore the general belief in earthquake engineering that infills develop a second line of defence against lateral forces in seismically deficient frames is nullified in case of low-strength infill walls in the presented experimental research.