Different Types of Cell Cycle- and Apoptosis-Related Gene Expressions Alter in Corticosteroid-, Vincristine-, and Melphalan-Resistant U-266 Multiple Myeloma Cell Lines
TURKISH JOURNAL OF HEMATOLOGY, vol.31, no.3, pp.231-238, 2014 (SCI-Expanded, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 31 Issue: 3
- Publication Date: 2014
- Doi Number: 10.4274/tjh.2013.0231
- Journal Name: TURKISH JOURNAL OF HEMATOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.231-238
- Keywords: Drug resistance, Multiple myeloma, Cell cycle, Apoptosis, BREAST-CANCER, PROTEIN, TSG-6, CD44, HYALURONAN, CONTAINS, CERAMIDE, BINDING, ARREST
- Middle East Technical University Affiliated: Yes
Abstract
Objective: Deregulation of the cell cycle and apoptosis mechanisms in normal cells causes many problems, including cancer. In this study, a genome-wide expression analysis of cell cycle- and apoptosis-related genes in corticosteroid-, vincristine-, and melphalan-resistant U-266 multiple myeloma cell lines was conducted.