Different Types of Cell Cycle- and Apoptosis-Related Gene Expressions Alter in Corticosteroid-, Vincristine-, and Melphalan-Resistant U-266 Multiple Myeloma Cell Lines

MUTLU P., Ural A. U., GÜNDÜZ U.

TURKISH JOURNAL OF HEMATOLOGY, vol.31, no.3, pp.231-238, 2014 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 3
  • Publication Date: 2014
  • Doi Number: 10.4274/tjh.2013.0231
  • Journal Name: TURKISH JOURNAL OF HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.231-238
  • Keywords: Drug resistance, Multiple myeloma, Cell cycle, Apoptosis, BREAST-CANCER, PROTEIN, TSG-6, CD44, HYALURONAN, CONTAINS, CERAMIDE, BINDING, ARREST
  • Middle East Technical University Affiliated: Yes

Abstract

Objective: Deregulation of the cell cycle and apoptosis mechanisms in normal cells causes many problems, including cancer. In this study, a genome-wide expression analysis of cell cycle- and apoptosis-related genes in corticosteroid-, vincristine-, and melphalan-resistant U-266 multiple myeloma cell lines was conducted.