Molecular structure, regulation and subcellular distribution of mu opioid receptors during postnatal development

Szucs M., ÖKTEM H. A., Szuts V., Lengyel I., Toth G., Coscia C., ...More

The International Narcotics Research Conference, 8 - 13 July 1989, pp.250, (Full Text) identifier

  • Publication Type: Conference Paper / Full Text
  • Page Numbers: pp.250
  • Middle East Technical University Affiliated: Yes

Abstract

Brains of mature and neonatal (P-3) rats were subjected to subcellular fractionation. Light membranes of P-3 contained more [3H]DAGO binding sites (40% of total μ sites vs 16% in adult) with greater sensitivity to GTP. Affinity labelling with [3H]DAGOCK revealed that the major subunit has a molecular weight of about 50 kDa in the synaptic as well as light membrane fractions.