Molecular structure, regulation and subcellular distribution of mu opioid receptors during postnatal development

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Atıf İçin Kopyala

Szucs M., ÖKTEM H. A., Szuts V., Lengyel I., Toth G., Coscia C., ...Daha Fazla

The International Narcotics Research Conference, 8 - 13 Temmuz 1989, ss.250

• Yayın Türü: Bildiri / Tam Metin Bildiri
• Sayfa Sayıları: ss.250
• Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Brains of mature and neonatal (P-3) rats were subjected to subcellular fractionation. Light membranes of P-3 contained more [3H]DAGO binding sites (40% of total μ sites vs 16% in adult) with greater sensitivity to GTP. Affinity labelling with [3H]DAGOCK revealed that the major subunit has a molecular weight of about 50 kDa in the synaptic as well as light membrane fractions.