Molecular structure, regulation and subcellular distribution of mu opioid receptors during postnatal development
The International Narcotics Research Conference, 8 - 13 Temmuz 1989, ss.250, (Tam Metin Bildiri)
- Yayın Türü: Bildiri / Tam Metin Bildiri
- Sayfa Sayıları: ss.250
- Orta Doğu Teknik Üniversitesi Adresli: Evet
Özet
Brains of mature and neonatal (P-3) rats were subjected to subcellular fractionation. Light membranes of P-3 contained more [3H]DAGO binding sites (40% of total μ sites vs 16% in adult) with greater sensitivity to GTP. Affinity labelling with [3H]DAGOCK revealed that the major subunit has a molecular weight of about 50 kDa in the synaptic as well as light membrane fractions.