Mechanical and biological evaluation of β-dicalcium silicate/dicalcium phosphate-based cements: promising materials for biomedical applications

Alshemary A. Z., Marandi A. B., Ali D., Köse T., Dalgic A. D., MOTAMENİ A., ...More

Journal of Taibah University for Science, vol.19, no.1, 2025 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 1
  • Publication Date: 2025
  • Doi Number: 10.1080/16583655.2025.2461817
  • Journal Name: Journal of Taibah University for Science
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Directory of Open Access Journals
  • Keywords: antibacterial activity, Biocements, compressive strength, cytotoxicity, dicalcium phosphate, β-dicalcium silicate
  • Middle East Technical University Affiliated: Yes

Abstract

This study explores the synthesis and evaluation of β-Dicalcium silicate and Dicalcium phosphate-based cements for biomedical use. β-Tricalcium phosphate was synthesized using microwave-assisted wet precipitation, while β-Dicalcium silicate was prepared via the sol-gel method. Composites with varying β-Dicalcium silicate contents (20%, 30%, 40%) were formulated and characterized using X-ray diffraction, Fourier-transform infrared spectroscopy, and Field emission scanning electron microscope analyses. The 40% β-Dicalcium silicate composite showed the highest compressive strength at 10.22 MPa. Antibacterial tests against Staphylococcus aureus revealed that gentamicin-loaded Dicalcium phosphate cement had superior properties. Cytotoxicity studies using the Osteogenic sarcoma cell line revealed that the β-Dicalcium Silicate /Dicalcium Phosphate composites supported better cell viability compared to pure Dicalcium phosphate cement, with the 20% β-Dicalcium silicate /Dicalcium phosphate composition being the most effective in promoting cell growth. These findings suggest that β-Dicalcium silicate /Dicalcium phosphate composites hold promise for biomedical applications.