Mechanical and biological evaluation of β-dicalcium silicate/dicalcium phosphate-based cements: promising materials for biomedical applications
Journal of Taibah University for Science, cilt.19, sa.1, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 19 Sayı: 1
- Basım Tarihi: 2025
- Doi Numarası: 10.1080/16583655.2025.2461817
- Dergi Adı: Journal of Taibah University for Science
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Directory of Open Access Journals
- Anahtar Kelimeler: antibacterial activity, Biocements, compressive strength, cytotoxicity, dicalcium phosphate, β-dicalcium silicate
- Orta Doğu Teknik Üniversitesi Adresli: Evet
Özet
This study explores the synthesis and evaluation of β-Dicalcium silicate and Dicalcium phosphate-based cements for biomedical use. β-Tricalcium phosphate was synthesized using microwave-assisted wet precipitation, while β-Dicalcium silicate was prepared via the sol-gel method. Composites with varying β-Dicalcium silicate contents (20%, 30%, 40%) were formulated and characterized using X-ray diffraction, Fourier-transform infrared spectroscopy, and Field emission scanning electron microscope analyses. The 40% β-Dicalcium silicate composite showed the highest compressive strength at 10.22 MPa. Antibacterial tests against Staphylococcus aureus revealed that gentamicin-loaded Dicalcium phosphate cement had superior properties. Cytotoxicity studies using the Osteogenic sarcoma cell line revealed that the β-Dicalcium Silicate /Dicalcium Phosphate composites supported better cell viability compared to pure Dicalcium phosphate cement, with the 20% β-Dicalcium silicate /Dicalcium phosphate composition being the most effective in promoting cell growth. These findings suggest that β-Dicalcium silicate /Dicalcium phosphate composites hold promise for biomedical applications.