Synthesis and characterization boron-doped hydroxyapatite for bone tissue engineering applications

Akbaba S., Pazarçeviren E., Turaçlı Karagüven S. Ö., EVİS Z., TEZCANER A.

Solid State Sciences, cilt.167, 2025 (SCI-Expanded, Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 167
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1016/j.solidstatesciences.2025.107989
  • Dergi Adı: Solid State Sciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Biotechnology Research Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
  • Anahtar Kelimeler: Bioceramics, Bone tissue engineering, Boron, Hydroxyapatite
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

In this study, the effect of dopant ratio on structural and biological properties of B-doped hydroxyapatite (HA) sintered at 500 °C was investigated for the first time. For this purpose, 1, 2, 4 and 8 mol% B-doped HA groups were synthesized. Presence of PO43− and BO33− groups were verified with Fourier-transform infrared spectroscopy (FTIR). X-ray diffraction (XRD) analysis revealed that increasing the B ratio led to a decreasing trend for HA phase percentage, crystallinity, and crystallite size. Similarly, Ca/(P + B) ratio decreased with increasing dopant ratio. B was incorporated into the HA structure with around 50 % yield. Moreover, mean particle size significantly decreased by B-doping for all groups. Concordantly, BET analysis revealed that the surface area of the groups increased with increasing B ratio. Overall, doping of HA with 4 mol% B was shown to provide both proliferative and osteogenic effects on human adipose derived stem cells (hADSCs). Our findings suggest that B-doped HA sintered at 500 °C holds promise for bone tissue engineering applications.