Enantioselective reduction of ketones with borane catalyzed by cyclic beta-amino alcohols prepared from proline

Demir A., Mecitoglu I., Tanyeli C., Gulbeyaz V.

TETRAHEDRON-ASYMMETRY, vol.7, no.12, pp.3359-3364, 1996 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 12
  • Publication Date: 1996
  • Doi Number: 10.1016/s0957-4166(96)00443-0
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
  • Page Numbers: pp.3359-3364
  • Middle East Technical University Affiliated: Yes


New catalysts have been prepared from (S)- and (R)- proline and the asymmetric borane reduction of prochiral ketones using these catalysts has been studied. The secondary alcohols were obtained in 76-95% yield with 57-96% enantiomeric excesses. Copyright (C) 1996 Elsevier Science Ltd