Enantioselective reduction of ketones with borane catalyzed by cyclic beta-amino alcohols prepared from proline

Demir A., Mecitoglu I., Tanyeli C., Gulbeyaz V.

TETRAHEDRON-ASYMMETRY, cilt.7, sa.12, ss.3359-3364, 1996 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Sayı: 12
  • Basım Tarihi: 1996
  • Doi Numarası: 10.1016/s0957-4166(96)00443-0
  • Dergi Adı: TETRAHEDRON-ASYMMETRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
  • Sayfa Sayıları: ss.3359-3364
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

New catalysts have been prepared from (S)- and (R)- proline and the asymmetric borane reduction of prochiral ketones using these catalysts has been studied. The secondary alcohols were obtained in 76-95% yield with 57-96% enantiomeric excesses. Copyright (C) 1996 Elsevier Science Ltd