Enantioselective reduction of ketones with borane catalyzed by cyclic beta-amino alcohols prepared from proline
TETRAHEDRON-ASYMMETRY, vol.7, no.12, pp.3359-3364, 1996 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 7 Issue: 12
- Publication Date: 1996
- Doi Number: 10.1016/s0957-4166(96)00443-0
- Journal Name: TETRAHEDRON-ASYMMETRY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
- Page Numbers: pp.3359-3364
- Middle East Technical University Affiliated: Yes
Abstract
New catalysts have been prepared from (S)- and (R)- proline and the asymmetric borane reduction of prochiral ketones using these catalysts has been studied. The secondary alcohols were obtained in 76-95% yield with 57-96% enantiomeric excesses. Copyright (C) 1996 Elsevier Science Ltd