Synthesis and modifications of polyprethanes for biomedical purposes


Hasirci N., Aksoy E. A.

HIGH PERFORMANCE POLYMERS, cilt.19, ss.621-637, 2007 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1177/0954008307081203
  • Dergi Adı: HIGH PERFORMANCE POLYMERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.621-637
  • Anahtar Kelimeler: polyurethane, biocompatibility, blood compatibility, cell attachment, glow discharge, plasma, PLASMA GLOW-DISCHARGE, POLYURETHANE MEMBRANES, MECHANICAL-PROPERTIES, COPOLYMERS, SURFACES, STENTS, MODEL
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Polyurethanes are known as a class of polymers with very high 'hemocompatible' properties. In this study polyurethanes were prepared in various compositions and in medical purity without using any solvent, catalyst or additives. For the synthesis of polyurethanes, toluene diisocynate, diphenylmethane diisocynate or hexamethylene diisocynate were used as diisocyanate compounds and polypropylene-ethylene glycol or polypropylene glycol were used as polyol compounds. The surfaces were modified with plasma glow-discharge by using various gas atmospheres and by applying different powers. Some samples were also modified by heparin immobilization to increase the blood compatibility. Chemical structure, mechanical strength, thermal behavior, oxygen permeability, water contact angle values, as well as protein and cell attachment capabilities of the prepared and modified polyurethanes were examined as possible candidates for biomedical applications. Plasma altered the chemistry of the surface, increased hydrophilic character, and caused a decrease in protein adsorption as the applied power was increased. On the other hand, an optimum power value which caused maximum attachment for Vero cells was observed. In-vitro experiments carried out with blood cells, plasma modification caused an increase on cell adhesion while further heparin immobilization resulted with a significant decrease.