Atom-transfer radical addition (ATRA) and cyclization (ATRC) reactions catalyzed by a mixture of [RuCl2Cp*(PPh3)] and magnesium


Thommes K., Icli B., Scopelliti R., Severin K.

CHEMISTRY-A EUROPEAN JOURNAL, vol.13, no.24, pp.6899-6907, 2007 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 24
  • Publication Date: 2007
  • Doi Number: 10.1002/chem.200700442
  • Journal Name: CHEMISTRY-A EUROPEAN JOURNAL
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.6899-6907
  • Keywords: catalysis, cyclization, magnesium, radical reactions, ruthenium, SUPPORTED ARYLNICKEL(II) CATALYSTS, MEDIUM-SIZED LACTONES, ARENESULFONYL CHLORIDES, HOMOGENEOUS CATALYSIS, SIMULTANEOUS REVERSE, SULFONYL CHLORIDES, NORMAL INITIATION, RUTHENIUM, COMPLEXES, OLEFINS

Abstract

A new catalytic procedure for atom-transfer radical addition (ATRA) and cyclization (ATRC) reactions is described. The combination of the ruthenium(III) complex [RuCl2-Cp*(PPh3)] (Cp*: pentamethylcyclopentadienyl) with magnesium allows these reactions to be performed under mild conditions with high efficiency. In most cases, the catalyst concentrations required are significantly lower than those used in previously reported procedures. It is suggested that magnesium acts as a reducing agent that generates and regenerates the catalytically active ruthenium(II) species. ne precatalyst [RuCl2Cp*(PPh3)] has been analyzed by X-ray crystallography.