In vitro synergy of caspofungin and amphotericin B against Aspergillus and Fusarium spp.

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Arikan S., Lozano-Chiu M., Paetznick V., Rex J.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol.46, no.1, pp.245-247, 2002 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 46 Issue: 1
• Publication Date: 2002
• Doi Number: 10.1128/aac.46.1.245-247.2002
• Journal Name: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.245-247
• Middle East Technical University Affiliated: No

Abstract

We investigated the in vitro interaction of caspofungin and amphotericin B for clinical isolates of Aspergillus and Fusarium. Synergy tests were performed using the checkerboard method and following the NCCLS M38-P guidelines in Antibiotic Medium 3 broth supplemented to 2% glucose. Antagonism was not observed for any of the isolates tested. Caspofungin and amphotericin B were synergistic or synergistic to additive for at least half of the isolates.