A new strategy for the synthesis of pyridines from N-propargylic beta-enaminothiones
ORGANIC & BIOMOLECULAR CHEMISTRY, vol.17, pp.2529-2541, 2019 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 17
- Publication Date: 2019
- Doi Number: 10.1039/c8ob03180k
- Journal Name: ORGANIC & BIOMOLECULAR CHEMISTRY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.2529-2541
- Middle East Technical University Affiliated: Yes
Abstract
A new method for the synthesis of 2,4,5-trisubstituted pyridines from N-propargylic beta-enaminothiones is reported. beta-Enaminothiones were prepared by thionation of the corresponding beta-enaminones with Lawesson's reagent. When treated with diisopropylamine in DMF at room temperature, N-propargylic beta-enaminothiones yielded 2,4,5-trisubstituted pyridines in moderate to high yields, along with small amounts of 2-methylene-2,3-dihydro-1,4-thiazepines. The reaction was found to be general for a broad range of N-propargylic beta-enaminothiones and tolerated the presence of aromatic, heteroaromatic and aliphatic groups with electron-withdrawing and electron-donating substituents. The method could be widened to the internal alkyne-tethered N-propargylic beta-enaminothiones. This operationally simple method may provide rapid access to a library of functionalized pyridines of pharmacological interest.