Chiral phosphine oxide aziridinyl phosphonate as a Lewis base catalyst for enantioselective allylsilane addition to aldehydes

DOĞAN Ö. , Bulut A., Tecimer M. A.

TETRAHEDRON-ASYMMETRY, cilt.26, ss.966-969, 2015 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 26 Konu: 17
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.tetasy.2015.07.002
  • Sayfa Sayıları: ss.966-969


A series of chiral Lewis bases, phosphine oxide ferrocenyl aziridinyl methanol 1-4, phosphinyl aziridinyl phosphonates 5 and 6, and phosphine oxide aziridinyl phosphonates 7 and 8 were screened for allylsilane additions to aldehydes. Among the Lewis bases, 8 was found to catalyze the reaction by forming the product in up to 94% yield and with 77% ee. (C) 2015 Elsevier Ltd. All rights reserved.