Bioprinted scaffolds assembled as synthetic skin grafts by natural hydrogels containing fibroblasts and bioactive agents
International Journal of Polymeric Materials and Polymeric Biomaterials, cilt.73, sa.11, ss.927-945, 2024 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 73 Sayı: 11
- Basım Tarihi: 2024
- Doi Numarası: 10.1080/00914037.2023.2230339
- Dergi Adı: International Journal of Polymeric Materials and Polymeric Biomaterials
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex, INSPEC
- Sayfa Sayıları: ss.927-945
- Anahtar Kelimeler: 3D bioprinting, 3D printing, curcumin, skin graft, Vitamin-C
- Orta Doğu Teknik Üniversitesi Adresli: Evet
Özet
Hydrogel skin grafts provide a moist environment and act as a regenerative template to the newly formed tissue. In this study, we developed 3D-bio-printed hydrogels using methacrylated pectin and methacrylated gelatin together with an antibacterial agent (curcumin), a bioactive agent (Vitamin-C) and fibroblast cells. Curcumin release was almost 10 times higher at pH 7.4 than pH 5.0, and it demonstrated antimicrobial affinity against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli. The developed 3D-bio-printed hydrogels containing cells and bioactive agents demonstrated high cell viability, cell proliferation, and collagen production, and are promising skin graft candidates for the treatment of full-thickness problematic wounds.