Bioprinted scaffolds assembled as synthetic skin grafts by natural hydrogels containing fibroblasts and bioactive agents

Bostancı N. S., Büyüksungur S., Hasirci N., TEZCANER A.

International Journal of Polymeric Materials and Polymeric Biomaterials, cilt.73, sa.11, ss.927-945, 2024 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 73 Sayı: 11
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1080/00914037.2023.2230339
  • Dergi Adı: International Journal of Polymeric Materials and Polymeric Biomaterials
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex, INSPEC
  • Sayfa Sayıları: ss.927-945
  • Anahtar Kelimeler: 3D bioprinting, 3D printing, curcumin, skin graft, Vitamin-C
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Hydrogel skin grafts provide a moist environment and act as a regenerative template to the newly formed tissue. In this study, we developed 3D-bio-printed hydrogels using methacrylated pectin and methacrylated gelatin together with an antibacterial agent (curcumin), a bioactive agent (Vitamin-C) and fibroblast cells. Curcumin release was almost 10 times higher at pH 7.4 than pH 5.0, and it demonstrated antimicrobial affinity against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli. The developed 3D-bio-printed hydrogels containing cells and bioactive agents demonstrated high cell viability, cell proliferation, and collagen production, and are promising skin graft candidates for the treatment of full-thickness problematic wounds.