Akademik Veri Yönetim Sistemi
Annals of Biomedical Engineering, cilt.52, sa.4, ss.1078-1090, 2024 (SCI-Expanded)
This study proposes using magnetically induced currents in medical infrared imaging to increase the temperature contrast due to the electrical conductivity differences between tumors and healthy tissues. There are two objectives: (1) to investigate the feasibility of this active method for surface and deep tumors using numerical simulations, and (2) to demonstrate the use of this method through different experiments conducted with phantoms that mimic breast tissues. Tumorous breasts were numerically modeled and simulated in active and passive modes. At 750 kHz, the applied current was limited for breast tissue-tumor conductivities (0.3 S/m and 0.75 S/m) according to the local specific absorption rate limit of 10 W/kg. Gelatin-based and mashed potato phantoms were produced to mimic tumorous breast tissues. In the simulation studies, the induced current changed the temperature contrast on the imaging surface, and the tumor detection sensitivity increased by 4 mm. An 11-turn 70-mm-long solenoid coil was constructed, 20 A current was applied for deep tumors, and a difference of up to 0.4 (Formula presented.) C was observed in the tumor location compared with the temperature in the absence of the tumor. Similarly, a 23-turn multi-layer coil was constructed, and a temperature difference of 0.4 (Formula presented.) C was observed. The temperature contrast on the body surface changed, and the tumor detection depth increased with the induced currents in breast IR imaging. The proposed active thermal imaging method was validated using numerical simulations and in vitro experiments.