Synthesis of Novel Benzothiazole-Piperazine Derivatives and Their Biological Evaluation as Acetylcholinesterase Inhibitors and Cytotoxic Agents

GÜRDAL HAKGÖR, ENİSE; Turgutalp, Bengisu; Gulcan, Hayrettin; Ercetin, Tugba; Sahin, MUSTAFA; Durmaz, Irem; Cetin-Atalay, Rengul; Quoc Dat Nguyen, Quoc; Sippl, Wolfgang; YARIM YÜKSEL, MİNE

doi:10.2174/1871520617666170412153604

Synthesis of Novel Benzothiazole-Piperazine Derivatives and Their Biological Evaluation as Acetylcholinesterase Inhibitors and Cytotoxic Agents

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GÜRDAL HAKGÖR E. E. , Turgutalp B., Gulcan H. O. , Ercetin T., Sahin M. F. , Durmaz I., ...More

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, vol.17, no.13, pp.1837-1845, 2017 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 17 Issue: 13
Publication Date: 2017
Doi Number: 10.2174/1871520617666170412153604
Title of Journal : ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
Page Numbers: pp.1837-1845

Abstract

Objective and Method: A new series of benzothiazole-piperazine derivatives was synthesized and a complete chemical characterization of the novel compounds was provided. In vitro cytotoxic activities were screened against colorectal (HCT-116), breast (MCF-7) and hepatocellular (Huh7) cancer cell lines by Sulforhodamine B assay.