Synthesis of Novel Benzothiazole-Piperazine Derivatives and Their Biological Evaluation as Acetylcholinesterase Inhibitors and Cytotoxic Agents

GÜRDAL HAKGÖR, ENİSE; Turgutalp, Bengisu; Gulcan, Hayrettin; Ercetin, Tugba; Sahin, MUSTAFA; Durmaz, Irem; Cetin-Atalay, Rengul; Quoc Dat Nguyen, Quoc; Sippl, Wolfgang; YARIM YÜKSEL, MİNE

doi:10.2174/1871520617666170412153604

Synthesis of Novel Benzothiazole-Piperazine Derivatives and Their Biological Evaluation as Acetylcholinesterase Inhibitors and Cytotoxic Agents

Atıf İçin Kopyala

GÜRDAL HAKGÖR E. E. , Turgutalp B., Gulcan H. O. , Ercetin T., Sahin M. F. , Durmaz I., ...Daha Fazla

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, cilt.17, ss.1837-1845, 2017 (SCI İndekslerine Giren Dergi)

Cilt numarası: 17 Konu: 13
Basım Tarihi: 2017
Doi Numarası: 10.2174/1871520617666170412153604
Dergi Adı: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
Sayfa Sayıları: ss.1837-1845

Özet

Objective and Method: A new series of benzothiazole-piperazine derivatives was synthesized and a complete chemical characterization of the novel compounds was provided. In vitro cytotoxic activities were screened against colorectal (HCT-116), breast (MCF-7) and hepatocellular (Huh7) cancer cell lines by Sulforhodamine B assay.