Synthesis of Novel Benzothiazole-Piperazine Derivatives and Their Biological Evaluation as Acetylcholinesterase Inhibitors and Cytotoxic Agents


GÜRDAL HAKGÖR E. E. , Turgutalp B., Gulcan H. O. , Ercetin T., Sahin M. F. , Durmaz I., ...More

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, vol.17, no.13, pp.1837-1845, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 13
  • Publication Date: 2017
  • Doi Number: 10.2174/1871520617666170412153604
  • Title of Journal : ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Page Numbers: pp.1837-1845

Abstract

Objective and Method: A new series of benzothiazole-piperazine derivatives was synthesized and a complete chemical characterization of the novel compounds was provided. In vitro cytotoxic activities were screened against colorectal (HCT-116), breast (MCF-7) and hepatocellular (Huh7) cancer cell lines by Sulforhodamine B assay.