Nanoparticle-based drug delivery in cancer: the role of cell membrane structures

Yalcin S., Ozluer O., GÜNDÜZ U.

THERAPEUTIC DELIVERY, vol.7, no.11, pp.773-781, 2016 (ESCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 7 Issue: 11
  • Publication Date: 2016
  • Doi Number: 10.4155/tde-2016-0056
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Page Numbers: pp.773-781
  • Middle East Technical University Affiliated: Yes


Development of novel drug-delivery systems aims to specifically deliver anticancer drugs to tumor tissues and improve the efficiency of chemotherapy, while minimizing side effects of drugs on healthy tissues and organs. However, drug-delivery systems are confronted by membrane barriers and multiple drug resistance in cancer cells. In recent years, the obtained results indicate an important role of lipids, proteins and carbohydrates in apoptosis, drug transport and the process of cellular uptake of nanoparticles via endocytosis. This article discusses the hypothesis of the relationship between cell membrane structure and nanoparticles in cancer cells.