Akademik Veri Yönetim Sistemi
9th International Symposium on Biomolecular Archaeology (ISBA9), Toulouse, Fransa, 1 - 04 Haziran 2021, ss.96-97
How the advent of agriculture and social complexity changed human inbreeding
patterns is unclear. Ethnographic work suggests low levels of consanguinity in
modern-day foragers compared to farmer communities. Meanwhile, the larger
population sizes of farmer societies may have lowered the frequency of panmictic
(i.e. drift-driven) inbreeding in these groups. Hence, the net impact of food production
on autozygosity levels remains unknown. Here we show that runs of homozygosity
(ROH) >1 Mb can be reliably estimated in genomes with ≥3x mean coverage per
SNP. We thus calculate the ROH-based inbreeding coefficient estimate, or FROH, in
411 published ancient Eurasian genomes from the last 15,000 years. We find that
FROH has significantly decreased over time, in both West and Central Eurasia. The
most dramatic reduction appears associated with the Neolithic Transition. Our results
hence suggest that population growth caused by food production, along with increased rates of human mobility, reduced the frequency of panmictic inbreeding
and led to a reduction in overall autozygosity. We find that cases of high
consanguinity are rare in our sample and are restricted to individuals from farmer
communities. Finally, we note that the high consanguinity levels observed in presentday Central Eurasia are not observed in ancient genomes, and this may therefore be
a recent phenomenon.