© 2022 Gazi Universitesi Muhendislik-Mimarlik. All rights reserved.Structural optimization of equipment mounted to payload carried externally by jet type fighter are performed by using the loads: artificial neural network (ANN) prediction, experimental and military specification. The main scope of this study is to evaluate the structural response limits proposed by military specifications with real test conditions and also compare the effects of usage ANN predicted and military specification loads in design of aerospace structures. Data used in this study is taken from physically representative Mark-83 with guidance units. Predefined vibration responses in structural optimization is used as power spectral density functions in the frequency domain. Loads for structural design are calculated with random loads using PSD data. Three sigma rule is considered between 20-300 Hz frequency bands. A support structure is optimized according to the ANN predictions, specification suggestions and experimental design loads. Supports designed based on experimental and predicted loads are observed to be lighter than the support designed according to the specification.