pH-Responsive Nano Carriers for Doxorubicin Delivery

Bagherifam S., Skjeldal F. M., Griffiths G., Maelandsmo G. M., Engebraten O., Nystrom B., ...More

PHARMACEUTICAL RESEARCH, vol.32, no.4, pp.1249-1263, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.1007/s11095-014-1530-0
  • Journal Name: PHARMACEUTICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1249-1263
  • Keywords: doxorubicin, nanocapsule, pH-responsive, poly L-histidine, polysebacic anhydride, NANOPARTICLES, RELEASE, CANCER, CYTOTOXICITY, MICELLES, POLYMER, SYSTEM, DRUGS, CELLS
  • Middle East Technical University Affiliated: Yes

Abstract

Purpose The aim of this study was to design stimuli-responsive nanocarriers for anti-cancer drug delivery. For this purpose, doxorubicin (DOX)-loaded, polysebacic anhydride (PSA) based nanocapsules (NC) were combined with pH-sensitive poly (L-histidine) (PLH).