pH-Responsive Nano Carriers for Doxorubicin Delivery

Bagherifam S., Skjeldal F. M., Griffiths G., Maelandsmo G. M., Engebraten O., Nystrom B., ...Daha Fazla

PHARMACEUTICAL RESEARCH, cilt.32, sa.4, ss.1249-1263, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/s11095-014-1530-0
  • Dergi Adı: PHARMACEUTICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1249-1263
  • Anahtar Kelimeler: doxorubicin, nanocapsule, pH-responsive, poly L-histidine, polysebacic anhydride, NANOPARTICLES, RELEASE, CANCER, CYTOTOXICITY, MICELLES, POLYMER, SYSTEM, DRUGS, CELLS
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Purpose The aim of this study was to design stimuli-responsive nanocarriers for anti-cancer drug delivery. For this purpose, doxorubicin (DOX)-loaded, polysebacic anhydride (PSA) based nanocapsules (NC) were combined with pH-sensitive poly (L-histidine) (PLH).