pH-Responsive Nano Carriers for Doxorubicin Delivery

Bagherifam, Shahla; Skjeldal, Frode; Griffiths, Gareth; Maelandsmo, Gunhild; Engebraten, Olav; Nystrom, Bo; Hasirci, VASIF; Hasirci, NESRİN

doi:10.1007/s11095-014-1530-0

pH-Responsive Nano Carriers for Doxorubicin Delivery

Bagherifam S., Skjeldal F. M., Griffiths G., Maelandsmo G. M., Engebraten O., Nystrom B., ...More

PHARMACEUTICAL RESEARCH, vol.32, no.4, pp.1249-1263, 2015 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 32 Issue: 4
Publication Date: 2015
Doi Number: 10.1007/s11095-014-1530-0
Journal Name: PHARMACEUTICAL RESEARCH
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1249-1263
Keywords: doxorubicin, nanocapsule, pH-responsive, poly L-histidine, polysebacic anhydride, NANOPARTICLES, RELEASE, CANCER, CYTOTOXICITY, MICELLES, POLYMER, SYSTEM, DRUGS, CELLS
Middle East Technical University Affiliated: Yes

Abstract

Purpose The aim of this study was to design stimuli-responsive nanocarriers for anti-cancer drug delivery. For this purpose, doxorubicin (DOX)-loaded, polysebacic anhydride (PSA) based nanocapsules (NC) were combined with pH-sensitive poly (L-histidine) (PLH).