The St. Regis Atlanta, one of the two five-star hotels located in Atlanta, Georgia, is a $150 million mixed-use building with 151 hotel rooms and 53 prestigious residences designed to meet the high expectations of the owner and architect. The distinctive architectural precast exterior combined with one-of-a-kind interior amenities creates a landmark building. With 26 stories including three underground levels, a two-story lobby with monumental staircase, and a tropicalparadise pool above an expansive hotel ballroom area, diverse structural analysis and design were required for the building. A 3D finite element model was developed to compute the dynamic characteristics of the building for both wind-tunnel tests and earthquake loads. This paper discusses the analysis and design of the post-tensioned concrete structure including the transfer beams, which accommodate transitions between the different occupancies of the building. It also presents the design challenges met for the design coordination of a mixed-usedhigh-rise building and the challenges that occurred during construction. © 2009 ASCE.