Etoposide resistance in MCF-7 breast cancer cell line is marked by multiple mechanisms

Alpsoy A., Yasa S., GÜNDÜZ U.

BIOMEDICINE & PHARMACOTHERAPY, cilt.68, sa.3, ss.351-355, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 68 Sayı: 3
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.biopha.2013.09.007
  • Dergi Adı: BIOMEDICINE & PHARMACOTHERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.351-355
  • Anahtar Kelimeler: Etoposide, Chemoresistance, Breast cancer, TOPOISOMERASE-II ACTIVITY, MULTIDRUG-RESISTANCE, GENE-EXPRESSION, SENSITIVITY, TOPBP1
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Purpose: Acquired or intrinsic drug resistance is one of the major handicaps in the success of chemotherapy. Etoposide is a topoisomerase II poison widely used in chemotherapy. Similar to other topoisomerase inhibitors and DNA damaging agents, resistance to etoposide may arise as a result of alterations in target expression and activity, increased drug efflux and alterations in DNA damage response mechanisms. Here, we tested the involvement of such mechanisms in etoposide-resistant MCF-7 breast cancer cells.