BIOMEDICINE & PHARMACOTHERAPY, vol.68, no.3, pp.351-355, 2014 (SCI-Expanded)
Article / Article
BIOMEDICINE & PHARMACOTHERAPY
Science Citation Index Expanded (SCI-EXPANDED), Scopus
Etoposide, Chemoresistance, Breast cancer, TOPOISOMERASE-II ACTIVITY, MULTIDRUG-RESISTANCE, GENE-EXPRESSION, SENSITIVITY, TOPBP1
Middle East Technical University Affiliated:
Purpose: Acquired or intrinsic drug resistance is one of the major handicaps in the success of chemotherapy. Etoposide is a topoisomerase II poison widely used in chemotherapy. Similar to other topoisomerase inhibitors and DNA damaging agents, resistance to etoposide may arise as a result of alterations in target expression and activity, increased drug efflux and alterations in DNA damage response mechanisms. Here, we tested the involvement of such mechanisms in etoposide-resistant MCF-7 breast cancer cells.